Design and synthesis of fluorescent probes for GPR54

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Design and synthesis of fluorescent probes for GPR54.

Kisspeptins are neuropeptides that induce the secretion of gonadotropin-releasing hormone via the activation of the cognate receptor, G-protein coupled receptor 54 (GPR54). The kisspeptin-GPR54 axis is associated with the onset of puberty and the maintenance of the reproductive system. In this study, several fluorescent probes have been designed and synthesized for rat GPR54 through the modific...

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ژورنال

عنوان ژورنال: Bioorganic & Medicinal Chemistry

سال: 2014

ISSN: 0968-0896

DOI: 10.1016/j.bmc.2014.04.052